CBD or cannabidiol is deprived of psychoactive properties, but it can help with various diseases
Recently, the main topics medical marijuana has been surfacing more and more often in foreign media, scientists are trying their finest to obtain permissions and funding for research in this region, believing in its promise, and in many countries of the world, decriminalization and legalization are underway.
Most hype now causes a substance such as for example CBD or cannabidiol contained in the hemp plant. Today it is found anywhere – from food to decorative cosmetics and quite legally purchased cbd gummies for sleep uk in internet vendors in the shape of oil. And all because CBD does not have psychoactive properties, unlike tetrahydrocannabinol (THC), but it has healing properties.
Since CBD is an active component of marijuana itself, you will get make money from it by smoking a joint in the old fashioned way. The most important thing is always to ensure that a grade with a predominance of this particular substance, rather than THC, is clogged in your joint in the event that you only want to relax and relieve anxiety or pain, and not, as usual, get stuck in the couch, unsuccessfully trying to manage paranoia.
Let’s attempt to figure out how this magical cannabidiol works, based on the latest data from the world of science and the knowledge of consumers using CBD as a medication, and not for fun.
The difference between the results of CBD and THC
Since cannabidiol is not a psychoactive substance, you can’t get high from it, but it’s easy to improve your productivity, relieve anxiety and relieve pain. When working with CBD, thoughts are not confused, memory does not deteriorate, and consequently of muscle relaxation, you don’t develop into a vegetable, as is the case with smoking cannabis varieties with a predominance of THC.
If the ratio of those substances is approximately the exact same, then you will find a small euphoric and the above-mentioned beneficial effects at the exact same time. At once, such negative consequences as paranoia, dry mouth, becoming dry and redness of the eyes, hunger and gluttony, drowsiness, and short-term memory problems, which are often caused by THC, don’t occur. Such varieties are usually used as a painkiller.
Although CBD works well alone, some experts still insist that in combination with other active the different parts of marijuana, it brings more benefits:
“To attain an improved therapeutic effect, you’ll need a mixture of cannabidiol, THC, and terpenoid phytochemicals,” says psychiatrist doctor at Harvard Medical School Lester Greenspoon.
However, how exactly this effect is achieved, scientists can not even say with accuracy. This knowledge gap is caused, to begin with, by too little research data, considering that the field of studying the healing properties of hemp remains in its infancy. Nevertheless the gradual legalization of medical marijuana implies that scientists will soon have significantly more freedom due to their experiments. So support the fists, hope and believe.
What diseases cannabidiol helps to deal with
Some scientific papers suggest that CBD has anti-inflammatory, analgesic and antipsychotic properties. In this regard, doctors hope that substance can help pharmaceutical companies to develop effective drugs against many disorders and diseases associated with similar symptoms.
The listing of such diseases includes, but is not limited to such pathological conditions:
To date, there are no full-fledged drugs predicated on CBD to combat these disorders, but many patients claim that the substance helps them to alleviate and even completely get rid of the symptoms.
Recently in the USA, where marijuana remains on the list of the very most dangerous psychoactive substances, there has been a real breakthrough in the field of pharmaceuticals – the Federal Food and Drug Administration (FDA) has approved the launch of the initial marijuana-based antiepileptic drug on the American market under Epidiolex name.
Its main component is precisely cannabidiol, the anticonvulsant aftereffect of that your FDA has confirmed with its tests. Today, Epidiolex can be used to deal with severe forms of epilepsy and such rare disorders that cause frequent and intense cramps in children, like Drave syndrome and Lenno-Gastaut syndrome.
And yet, before Epidiolex, there were other drugs based on the the different parts of marijuana. As an example, the Belgian company Solvay Pharmaceuticals back 1985 created Marinol (dronabinol), a medication that is simply a synthetic THC, which is still used today to improve the appetite of cancer patients undergoing chemotherapy.
In 2010, British pharmaceutical group GW Pharmaceuticals developed Sativex, a drug containing equal areas of CBD and THC, to relieve muscle cramps and other apparent symptoms of multiple sclerosis.
The mechanism of action of cannabidiol
Although there’s still less data on what CBD includes a beneficial influence on the human body, scientists still possess some ideas on this subject. Surprisingly, cannabidiol does not bind to the active sites of the cannabinoid receptors CB1 and CB2, as does the exact same THC. But it interacts with the GPR55 protein secreted in the brain and peripheral organs. Researchers believe that determines its antispasmodic effect.
In the brain, CBD regulates the synaptic transmission process, during which signaling molecules are transmitted from one neuron to another. The connections between these brain cells grow stronger when GPR55 is activated.
Convulsions occur when neurons become too active in signaling, flashing more often than necessary. Cannabidiol blocks the GPR55 protein, thus preventing overload of the synaptic transmission system, according to Ben Wally, head of research at GW Pharmaceuticals.
The partnership of the protein with CBD is confirmed by experiments with genetically modified rodents in which epileptic seizures were caused. Those animals in which GPR55 was present responded to cannabidiol treatment, and rats without protein continued to have convulsions.
Wally also believes that CBD can contribute to the desensitization of the TRPV1 protein, which is mixed up in transport of ions and calcium in the torso, which also helps relieve cramping. First, cannabidiol activates this protein, however quickly decreases the sensitivity of the ion channel, effectively blocking the transport of calcium into cells. By analogy with GPR55, animals that lack TRPV1 don’t answer CBD.
Finally, this substance interacts with the channel of transport of adenosine, an anticonvulsant substance made by the body. Wally believes that cannabidiol suppresses seizures, mainly because of its influence on adenosine, but more experiments are essential to ensure this hypothesis.
Such a wide range of areas in which CBD is active allows scientists to suggest that substance may be useful in the treating motor disorders, such as for example Parkinson’s disease. And the interaction with serotonin receptors implies that cannabidiol can be used to deal with depression, anxiety and psychotic stages of bipolar disorder and schizophrenia.
Nevertheless, many researchers, such as for example Roger Pertwee, a professor at the University of Aberdeen and the top of the pharmacology department of GW Pharmaceuticals, insist that without clinical data it can not be confidently stated that the interaction of CBD with your receptors and proteins means that it causes a therapeutic aftereffect of this substance.
High CBD Marijuana Varieties
Finally, we will provide you with a list of popular cannabidiol-dominated varieties so you know what to ask about next time in your telegram supermarket: