Marijuana — Will it be An incredibly Risky Pill?

Have a deep breath!

In 2012, a study at the University of California, San Francisco (UCSF) calculated that even smoking a single joint every single day for 20 years may be benign, though most participants only smoked several joints each month. “I was surprised we didn’t see effects [of marijuana use],” said UCSF epidemiologist Mark Pletcher, who led the study.

One assessment of varied epidemiological studies points to small sample size and poor study design as reasons for scientists’inability to nail down a link between cannabis and cancer risk. However many suspect that this kind of link doesn’t exist, and that marijuana might even have cancer-preventive effects. How does 1000mg CBD Gummies compare against 500mg and 250mg CBD gummy bears? A 2008 study, for instance, suggested that smoking marijuana may reduce the chance of tobacco-associated lung cancer, calculating that people who smoke both marijuana and tobacco have less risk of cancer than those that smoke only tobacco (though still a greater risk than non-smokers).

But even Pletcher isn’t sanguine about marijuana’s effects on the lungs, and suspects that there could nevertheless be long-term lung damage which can be hard to detect. “We really can’t reassure ourselves about heavy use,” he explained.

Your brain on drugs

There’s some evidence to claim that stoned subjects exhibit increased risk-taking and impaired decision-making, and score worse on memory tasks-and residual impairments have now been detected days or even weeks after use. Some studies also link years of regular marijuana use to deficits in memory, learning, and concentration. A current and widely discussed report on the IQs of New Zealanders followed since birth found that cannabis users who’d started their habit in adolescence had lower IQs than non-users.

In this study, led by researchers at Duke University, “you could clearly see as a consequence of cannabis use, IQ decreases,” said Derik Hermann, a scientific neuroscientist at the Central Institute of Mental Health in Germany who was not involved in the research.

Although not 4 months later, a re-analysis and computer simulation at the Ragnar Frisch Center for Economic Research in Oslo countered the Duke findings. Ole Rogeberg contended that socioeconomic factors, not marijuana use, contributed to the reduced IQs seen in cannabis users.

Rogeberg’s conclusion counters a substantial literature, however, which supports a link between pot use and neurophysiological decline. Studies in both humans and animals suggest that people who acquiring a marijuana habit in adolescence face long-term negative impacts on brain function, with some users finding it difficult to concentrate and learn new tasks.

Notably, most studies on the subject claim that while there could be negative consequences of smoking as a young adult, users who begin in adulthood are generally unaffected. This might be because of endocannabinoid-directed reorganization of the brain during puberty, Hermann explained. The intake of cannabinoids that is included with pot use might cause irreversible “misleading of the neural growth,” he said.

As well as the consequences for intelligence, many studies claim that smoking marijuana raises the chance of schizophrenia, and may have similar effects on the brain. Hermann’s group used MRI to detect cannabis-associated neuron damage in the pre-frontal cortex and found so it was similar to brain changes seen in schizophrenia patients. Other studies further claim that weed-smoking schizophrenics have greater disease-associated brain changes and perform worse on cognitive tests than their non-smoking counterparts.

But much of this research can’t distinguish between brain changes resulting from marijuana use and symptoms associated with the disease. It’s possible that cannabis-smoking schizophrenics “could have unpleasant symptoms [that precede full-blown schizophrenia] and are self-medicating” with the psychotropic drug, said Roland Lamarine, a professor of community health at California State University, Chico. “We haven’t seen a growth in schizophrenics, despite a lot more marijuana use.”

In fact, other research suggests that cannabis-using schizophrenics score better on cognitive tests than non-using schizophrenics. Such conflicting reports may be as a result of varying concentrations-and varying effects-of cannabinoids in marijuana. As well as tetrahydrocannabinol (THC), a neurotoxic cannabinoid that is accountable for marijuana’s mind-altering properties, the drug also contains a number of non-psychoactive cannabinoids, including cannabidiol (CBD), which could protect against neuron damage. Hermann found that the amount of the hippocampus-a brain area very important to memory processing-is slightly smaller in cannabis users than in non-users, but more CBD-rich marijuana countered this effect.

A fatal cocktail?

While data supporting the harmful ramifications of marijuana on its own are weak, some researchers are far more concerned about the drug along with other substances, such as tobacco, alcohol, or cocaine. Some studies suggest, for instance, that marijuana may increase cravings for other drugs, resulting in its infamous tag as a “gateway drug.” A study published earlier this month supported this theory when it found that, at the least in rats, THC exposure increases tobacco’s addictive effects. Furthermore, marijuana might not mix well with prescription drugs, as cannabis causes the liver to metabolize drugs more slowly, raising the chance of drug toxicity.

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